The twenty one children with kawasaki disease who were diagnosed and treated through admission at Wonkwang University Hospital for recent 3 years were investigated for clinical patterns and laboratory correlations.
We devided the patients into two-groups in the methods of medical drug usuage Group A ; aspirin only, Group B ; aspirin plus intravenous gamma globulin. The results were as follows ;
(1) The average duration of fever was 10 to 11 days.
(2) The principal signs during admission were fever, changes of lips and oral mucosa (95 %, respectively), changes of peripheral extremities, polymorphous exanthema (81 %, respectively), bilateral conjunctival congestion (67 %), cervical lymphadenopathy (62 %) in descending order.
(3) The main laboratory findings were positive-CRP (89 % ), elevated ESR (81 % ), leukocytosis (72 %), increased ALT and pyuria (71 %, respectively), proteinuria (43 %) in descending order.
The average period of peak elevation of platelets was 10 to 14 days beyond the onset of fever.
(4) We observed the coronary abnormalities at 6 patients (34 % )
Saccular aneurysm of left main coronary artery was developed in one patient who was medicated with aspirin only. But, in five patients (28 %) of double treatment with aspirin and intravenous gamma globulin, we observed a diffuse dilatation of the largest single or both coronary arteries.
Those abnormal findings became normalized in periods of 3 to 6 months after the onset of fever.
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